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Proteintech
THOC5 Recombinant Rabbit Monoclonal Antibody (240013F7), CoraLite® Plus 488
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Product Details
CL488-83435
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
240013F7
Immunogen
THOC5 fusion protein Ag6664
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: CKDDSVLHLT FYYLMNLNIM TVKAKVTTAM ELITPISAGD LLSPDSVLSC LYPGDHGKKT PNPANQYQFD KVGILTLSDY VLELGHPYLW VQKLGGLHFP KEQPQQTVIA DHSLSASHME TTMKLLKTRV QSRLALHKQF ASLEHGIVPV TSDCQYLFPA KVVSRLVKWV TIAHEDYMEL HFTKDIVDAG LAGDTNLYYM ALIERGTAKL QAAVVLNPGY SSIPPIFQLC LNWKGEKTNS NDDNIRAMEG EVNVCYKELC GPWPSHQLLT NQLQRLCVLL DVYLETESHD DSVEGPKEFP QEKMCLRLFR GPSRMKPFKY NHPQGFFSHR
Target Information
Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fms-interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; PP39.2; THO complex 5; THO complex subunit 5
Gene Aliases: C22orf19; Fmip; fSAP79; KIAA0983; PK1.3; THOC5
UniProt ID: (Human) Q13769
Entrez Gene ID: (Human) 8563
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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