FIGURE: 1 / 2
Immunogen sequence: RLLNYLLDNL SGTAKRITTE QPPPRSWIML QEPDRTRPTA LFSVMCYN
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 88%.
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: carbon catabolite repression 4 protein; carbon catabolite repressor protein 4 homolog; CCR4-NOT transcription complex, subunit 6; cytoplasmic deadenylase
Gene Aliases: CCR4; Ccr4a
Entrez Gene ID: (Human) 57472
Molecular Function: mRNA polyadenylation factor