|Tested species reactivity||Bovine, Horse, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (106 QHNQWPMGELTC 116) of CXCR7/RDC1 protein.|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1-10 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||4-6 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CXCR7/RDC1 is a 362 amino acid CXC chemokine receptor involved in a number of pathobiologic processes, including cell growth, survival and adhesion, and tumor growth. It belongs to the G-protein coupled receptor 1 family. Though CXCR7 was previously identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered as an orphan receptor in that its endogenous ligand has not been identified. It is an alternative receptor for CXCL12/SDF1 and ITAC (CXCL11) as well as acts as a co-receptor with CXCR4 for a restricted number of HIV isolates. Reports suggest that CXCR7 may act as a link between inflammation and cancer. This membrane protein is usually expressed in monocytes, basophils, and B-cells while low expression is also seen in CD4+ T-lymphocytes and natural killer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.