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Alomone Labs, LTD
Caspr2 Polyclonal Antibody
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FIGURE: 1 / 2
Caspr2 Antibody (APZ-005-200UL) in IHC (F)
Expression of Caspr2 in rat cerebellum - Immunohistochemical staining of rat brain frozen sections using Anti-Caspr2 Antibody (#APZ-005), (1:200), (green). A. Caspr2 appears in pinceau structures (arrows) and diffusely in the molecular layer (MOL). Staining of the same section for parvalbumin (red) labels Purkinje cells and demonstrates the position of the pinceau under Purkinje cells. B. Pre-incubation of ... View More
Product Details
APZ-005-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.4 mg/mL
Amount
80 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell recognition molecule Caspr2; contactin associated protein like 2; contactin associated protein-like 2; Contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; unnamed protein product
Gene Aliases: 5430425M22Rik; AUTS15; CASPR2; CDFE; CNTNAP2; KIAA0868; mKIAA0868; NRXN4; PTHSL1
UniProt ID: (Human) Q9UHC6, (Mouse) Q9CPW0
Entrez Gene ID: (Human) 26047, (Rat) 500105, (Mouse) 66797
startle response
cell adhesion
central nervous system development
brain development
learning
neuron recognition
cell proliferation
transmission of nerve impulse
striatum development
limbic system development
thalamus development
cerebral cortex development
adult behavior
neuron projection development
social behavior
vocal learning
clustering of voltage-gated potassium channels
neuron projection morphogenesis
prepulse inhibition
superior temporal gyrus development
protein localization to juxtaparanode region of axon
vocalization behavior
positive regulation of gap junction assembly
cellular protein localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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