Search

  • Fale Conosco
  • Pedido rápido

Invitrogen

DRD3 Polyclonal Antibody

View all (14) DRD3 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
DRD3 Polyclonal Antibody

Product Details

PA5-79170

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Dopamine Receptor D3 (352-367aa NTHCQTCHVSPELYSA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

5mg BSA, 0.9mg NaCl, 0.2mg Na2PO4

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746286

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Testis Tissue, Rat Brain Tissue, U87 Cell, HELA Cell. IHC: Rat Brain Tissue.

Target Information

This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: D(3) dopamine receptor; D3 receptor; D3nf; Dopamine 3 receptor; Dopamine D3 receptor; dopamine receptor 3; dopaminergic receptor D3; essential tremor 1; unnamed protein product

View more View less

Gene Aliases: D3DR; D3R; DRD3; ETM1; FET1

View more View less

UniProt ID: (Human) P35462, (Rat) P19020, (Mouse) P30728

View more View less

Entrez Gene ID: (Human) 1814, (Rat) 29238, (Mouse) 13490

View more View less

Function(s)
dopamine neurotransmitter receptor activity, coupled via Gi/Go G-protein coupled receptor activity dopamine neurotransmitter receptor activity protein binding drug binding protein domain specific binding D1 dopamine receptor binding dopamine binding signal transducer activity G-protein coupled amine receptor activity G-protein coupled receptor
Process(es)
synaptic transmission, dopaminergic G-protein coupled receptor internalization cellular calcium ion homeostasis signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway learning or memory learning locomotory behavior visual learning response to xenobiotic stimulus regulation of dopamine secretion positive regulation of cytokinesis circadian regulation of gene expression response to histamine social behavior response to cocaine dopamine metabolic process regulation of potassium ion transport response to morphine response to ethanol negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of blood pressure positive regulation of mitotic nuclear division acid secretion behavioral response to cocaine negative regulation of oligodendrocyte differentiation arachidonic acid secretion negative regulation of protein secretion musculoskeletal movement, spinal reflex action negative regulation of cytosolic calcium ion concentration regulation of dopamine uptake involved in synaptic transmission negative regulation of protein kinase B signaling regulation of amine transport negative regulation of synaptic transmission, glutamatergic prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of secretion by cell negative regulation of transcription from RNA polymerase II promoter response to amphetamine regulation of blood volume by renin-angiotensin negative regulation of adenylate cyclase activity dopamine receptor signaling pathway chemical synaptic transmission positive regulation of cell proliferation regulation of lipid metabolic process regulation of cAMP metabolic process negative regulation of sodium:proton antiporter activity gastric emptying positive regulation of renal sodium excretion regulation of locomotion regulation of multicellular organism growth response to drug regulation of circadian sleep/wake cycle, sleep positive regulation of transcription from RNA polymerase II promoter negative regulation of dopamine receptor signaling pathway regulation of locomotion involved in locomotory behavior sensory perception of chemical stimulus
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support