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Invitrogen
DYNLL1 Polyclonal Antibody
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Product Details
PA5-47957
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human PIN
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1, 200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; DLC1DNCLC1; DLC8; DLC8MGC126137; DNCL1; DNCL1MGC126138; Dynein light chain 1, cytoplasmic; Dynein light chain LC8-type 1; dynein, cytoplasmic, light polypeptide 1; H LC8; LC8-type 1; MGC126137; MGC126138; PIN; PINLC8a; Protein inhibitor of neuronal nitric oxide synthase; unnamed protein product
Gene Aliases: DLC1; DLC8; DNCL1; DNCLC1; DYNLL1; HDLC1; LC8; LC8a; PIN
UniProt ID: (Human) P63167
Entrez Gene ID: (Human) 8655
apoptotic process
cellular response to DNA damage stimulus
microtubule-based process
spermatid development
substantia nigra development
positive regulation of intracellular transport
intraciliary retrograde transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of phosphorylation
motile cilium assembly
negative regulation of nitric oxide biosynthetic process
DNA strand resection involved in replication fork processing
negative regulation of DNA strand resection involved in replication fork processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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