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E2F1 Polyclonal Antibody

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E2F1 Polyclonal Antibody

Product Details

BS-0599R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human E2F1, amino acids 101-180.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E2F-1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; retinoblastoma-binding protein 3 (E2F-like); transcription factor E2F like protein; Transcription factor E2F1

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Gene Aliases: E2F-1; E2F1; mKIAA4009; RBAP1; RBBP3; RBP3

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UniProt ID: (Human) Q01094, (Mouse) Q61501, (Rat) O09139

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Entrez Gene ID: (Human) 1869, (Mouse) 13555, (Rat) 399489

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding sequence-specific DNA binding protein dimerization activity binding, bridging DNA-binding transcription factor binding sequence-specific double-stranded DNA binding core promoter binding transcription factor binding transcription regulatory region DNA binding RNA metabolism protein nucleic acid metabolism protein general transcription factor
Process(es)
DNA damage checkpoint negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of gene expression forebrain development response to lipopolysaccharide positive regulation of apoptotic process anoikis negative regulation of DNA binding negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation mRNA stabilization regulation of cell cycle positive regulation of glial cell proliferation negative regulation of fat cell proliferation cellular response to fatty acid cellular response to hypoxia cellular response to xenobiotic stimulus intrinsic apoptotic signaling pathway by p53 class mediator lens fiber cell apoptotic process cellular response to nerve growth factor stimulus regulation of G1/S transition of mitotic cell cycle cell cycle negative regulation of transcription involved in G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle
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