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EPHA2 Polyclonal Antibody

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EPHA2 Polyclonal Antibody

Product Details

BS-10209R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human EPHA2, amino acids 401-500.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2; unnamed protein product

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Gene Aliases: ARCC2; AW545284; CTPA; CTPP1; CTRCT6; ECK; EPHA2; Myk2; Sek-2; Sek2

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UniProt ID: (Human) P29317, (Mouse) Q03145

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Entrez Gene ID: (Human) 1969, (Mouse) 13836, (Rat) 366492

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Function(s)
nucleotide binding virus receptor activity protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding kinase activity transferase activity growth factor binding cadherin binding molecular function activator activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
skeletal system development angiogenesis blood vessel development vasculogenesis osteoblast differentiation negative regulation of cytokine production blood vessel endothelial cell proliferation involved in sprouting angiogenesis apoptotic process response to stress inflammatory response cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation cell migration negative regulation of angiogenesis neural tube development central nervous system neuron differentiation cell differentiation regulation of cell adhesion keratinocyte differentiation osteoclast differentiation regulation of cell migration positive regulation of cell migration epithelial cell differentiation negative regulation of chemokine production mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis regulation of blood vessel endothelial cell migration regulation of angiogenesis cAMP metabolic process viral entry into host cell bone remodeling ephrin receptor signaling pathway axial mesoderm formation animal organ development blood vessel morphogenesis notochord morphogenesis cell motility defense response to Gram-positive bacterium notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor protein localization to plasma membrane activation of GTPase activity negative regulation of lymphangiogenesis positive regulation of protein localization to plasma membrane positive regulation of bicellular tight junction assembly pericyte cell differentiation protein phosphorylation phosphorylation peptidyl-tyrosine phosphorylation neuron differentiation protein kinase B signaling negative regulation of protein kinase B signaling positive regulation of establishment of protein localization to plasma membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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