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Product Details
PA5-65909
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human GPATCH3. Recombinant protein control fragment (Product #RP-105006).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2664406
Product Specific Information
Immunogen sequence: RHTKGIGRKVM ERQGWAEGQG LGCRCSGVPE ALDSDGQHPR CKRGLGYHGE KLQPFGQLKR PRRNGLGLIS TIYDEPLPQD QTES
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 89%.
Target Information
GPATCH3 is a protein coding gene involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G patch domain containing 3; G patch domain-containing protein 3
Gene Aliases: GPATC3; GPATCH3
UniProt ID: (Human) Q96I76
Entrez Gene ID: (Human) 63906
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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