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Invitrogen
GPR56 Polyclonal Antibody
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FIGURE: 1 / 4
GPR56 Antibody (720373) in ICC/IF
HEK 293 cells were grown on poly-L-lysine-coated coverslips overnight. Cells were then transiently transfected with GPR56. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with Anti-GPR56 Rabbit Polyclonal Antibody (Product # 720373 at a concentration of 2 µg/mL). Cells were then incubated with Alexa488-conjugated secondary antibody for 2... View More
Product Details
720373
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human ADGRG1 (aa 252-265)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Cat and Bovine.
Target Information
GPR56 is a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 7-transmembrane protein with no EGF-like N-terminal domains-1; Adhesion G-protein coupled receptor G1; Cyt28; DKFZp781L1398; G protein-coupled receptor 56; G-protein coupled receptor 56; SLR32; testicular tissue protein Li 77; unnamed protein product
Gene Aliases: ADGRG1; BFPP; BPPR; CDCBM14B; CDCBM15A; GPR56; TM7LN4; TM7XN1; UNQ540/PRO1083
UniProt ID: (Human) Q9Y653
Entrez Gene ID: (Human) 9289
angiogenesis
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
cell-cell signaling
nervous system development
brain development
negative regulation of cell proliferation
positive regulation of signal transduction
cell migration
cerebral cortex regionalization
cerebral cortex radial glia guided migration
layer formation in cerebral cortex
cell differentiation
positive regulation of Rho protein signal transduction
tube development
regulation of cell proliferation
positive regulation of cell adhesion
anatomical structure formation involved in morphogenesis
neural precursor cell proliferation
hematopoietic stem cell homeostasis
seminiferous tubule development
regulation of platelet aggregation
negative regulation of ferroptosis
Rho-activating G protein-coupled receptor signaling pathway
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of neural precursor cell proliferation
negative regulation of neuron migration
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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