Invitrogen

HEXIM2 Polyclonal Antibody

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HEXIM2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of HEXIM2 in paraffin embedded human testis tissue using a HEXIM2 polyclonal antibody (Product # PA5-97827) at a dilution of 1:100.

HEXIM2 Antibody in Western Blot (WB) — Western Blot analysis of HEXIM2 using a HEXIM2 Polyclonal antibody (Product # PA5-97827) at a concentration of 3 µg/mL. Positive WB detected in: Rat liver tissue, Mouse kidney tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 33 kDa.

Product Details

PA5-97827

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:5,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
ELISA (ELISA)	Assay-Dependent	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant Human Protein HEXIM2 protein (1-286AA) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	4.97 mg/mL
Purification	Protein G
Storage buffer	PBS, pH 7.4, with 50% glycerol
Contains	0.03% Proclin 300
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2812441

Target Information

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hexamethylene bis-acetamide inducible 2; Hexamethylene bis-acetamide-inducible protein 2; hexamethylene-bis-acetamide-inducible transcript 2; hexamthylene bis-acetamide inducible 2; MAQ1 paralog; Protein HEXIM2

Gene Aliases: 4933402L21Rik; HEXIM2; L3; RGD1311635

UniProt ID: (Human) Q96MH2, (Mouse) Q3TVI4

Entrez Gene ID: (Human) 124790, (Rat) 303580, (Mouse) 71059

Function(s)

negative regulation of transcription from RNA polymerase II promoter biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated

Process(es)

cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding snRNA binding 7SK snRNA binding molecular_function