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HS6ST1 Polyclonal Antibody
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Product Details
BS-10701R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HS6ST1, amino acids 311-411.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The HS6ST1 gene encodes the enzyme heparan sulfate 6-O-sulfotransferase 1, which is essential for the biosynthesis of heparan sulfate (HS) glycosaminoglycans by adding sulfate groups to the 6th position of glucosamine residues within HS chains. HS6ST1 is vital for numerous biological processes, including modulating the activity of growth factors, cytokines, and chemokines, which are influenced by HS structures on the cell surface and extracellular matrix. This sulfation step is critical for the proper functioning of developmental pathways and neuronal signaling, impacting brain development and function. Mutations in HS6ST1 have been associated with intellectual disabilities and developmental disorders such as hypogonadotropic hypogonadism and Kallmann syndrome, characterized by impaired sense of smell and delayed puberty. Moreover, altered HS6ST1 expression is implicated in cancer progression by affecting tumor growth, angiogenesis, and metastasis through altered HS interactions with signaling molecules. Its role in modulating receptor-ligand interactions makes HS6ST1 a promising target for therapeutic interventions aimed at repairing defective signaling pathways associated with genetic disorders and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Heparan-sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-sulfotransferase; HS6ST-1; mHS6ST-1; unnamed protein product
Gene Aliases: 6Ost1; HH15; HS6ST; HS6ST1
UniProt ID: (Human) O60243, (Mouse) Q9QYK5
Entrez Gene ID: (Human) 9394, (Mouse) 50785, (Rat) 316325
protein binding
sulfotransferase activity
transferase activity
heparan sulfate 6-O-sulfotransferase activity
N-acetylglucosamine 6-O-sulfotransferase activity
N-acetylgalactosamine 4-O-sulfotransferase activity
heparan sulfate 2-O-sulfotransferase activity
HNK-1 sulfotransferase activity
trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
1-phenanthrol sulfotransferase activity
3-phenanthrol sulfotransferase activity
4-phenanthrol sulfotransferase activity
trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
9-phenanthrol sulfotransferase activity
2-phenanthrol sulfotransferase activity
phenanthrol sulfotransferase activity
1-hydroxypyrene sulfotransferase activity
galactose 3-O-sulfotransferase activity
proteoglycan sulfotransferase activity
cholesterol sulfotransferase activity
hydroxyjasmonate sulfotransferase activity
transferase
metabolite interconversion enzyme
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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