This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: SDLTPVVDAI TDALLAARPR RRYYPGQGLG LMYFIHYYLP EGLRRRFLQA FFISHCLPRA LQPGQPGTTP PQDAAQDPNL SPG
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 76%.
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: -HSD11 type II; 11-beta-HSD; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-hydroxysteroid dehydrogenase type II; 11-DH2; 11-HSD type II; AME; AME1; Corticosteroid 11-beta-dehydrogenase isozyme 2; HSD11K; HSD2; hydroxysteroid (11-beta) dehydrogenase 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; SDR9C3; short chain dehydroge; Short chain dehydrogenase/reductase family 9C member 3
Gene Aliases: AME; AME1; HSD11B2; HSD11K; HSD2; SDR9C3
UniProt ID: (Human) P80365
Entrez Gene ID: (Human) 3291