|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified recombinant human IL-1-alpha|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product is recommended as a capture antibody in Sandwich ELISA applications.
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Cyclodextrin polysulphates repress IL-1 and promote the accumulation of chondrocyte extracellular matrix.
AHC0912 was used in flow cytometry to study the influence of cyclodextrin polysulphate on the extracellular matrix metabolism of human articular cartilage chondrocytes
|Verdonk P,Wang J,Groeneboer S,Broddelez C,Elewaut D,Veys EM,Verbruggen G||Osteoarthritis and cartilage (13:887)||2005|
Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism.
AHC0912 was used in flow cytometry to examine the effects of hydrocortisone on synthesis and turnover of cell associated matrix by human chondrocytes.
|Wang J,Elewaut D,Hoffman I,Veys EM,Verbruggen G||Annals of the rheumatic diseases (63:61)||2004|
Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro.
AHC0912 was used in flow cytometry to study IGF-1/IGFR1 and IL-1/IL-1R pathways in osteoarthritic articular cartilage.
|Wang J,Verdonk P,Elewaut D,Veys EM,Verbruggen G||Osteoarthritis and cartilage (11:801)||2003|
Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage.
AHC0912 was used in flow cytometry to examine the effect of insulin-like growth factor 1 on human chondrocytes.
|Wang J,Elewaut D,Veys EM,Verbruggen G||Arthritis and rheumatism (48:1281)||2003|
|Human||Not Cited||Cytokine responses to treponema pectinovorum and treponema denticola in human gingival fibroblasts.||Nixon CS,Steffen MJ,Ebersole JL||Infection and immunity (68:5284)||2000|