Invitrogen

ILK Polyclonal Antibody

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ILK Polyclonal Antibody

Product Details

PA5-119671

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within Human Integrin linked ILK aa 1-290
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913244

Product Specific Information

Positive Control: Mouse skeletal muscle tissue, rat lung tissue, A431, MG-63, PANC-1, rat skeletal muscle tissue, human kidney tissue, human pancreas tissue, mouse heart tissue.

Subcellular Location: Cell junction, Cell membrane, Cytoplasm.

Target Information

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; ILK-1; ILK-2; Inactive integrin-linked kinase; integrin binding protein kinase; Integrin linked ILK; integrin linked kinase; integrin-linked kinase; integrin-linked kinase-2; integrin-linked protein kinase; p59ILK; Scaffold protein ILK

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Gene Aliases: AA511515; ESTM24; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK

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UniProt ID: (Human) Q13418, (Mouse) O55222, (Rat) Q99J82

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Entrez Gene ID: (Human) 3611, (Mouse) 16202, (Rat) 170922

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Function(s)
protein serine/threonine kinase activity signal transducer activity integrin binding protein binding ATP binding SH3 domain binding protein kinase binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein domain specific binding non-receptor serine/threonine protein kinase
Process(es)
branching involved in ureteric bud morphogenesis positive regulation of cell-matrix adhesion outflow tract morphogenesis protein phosphorylation negative regulation of protein kinase activity cell cycle arrest cell-matrix adhesion integrin-mediated signaling pathway cell aging cell proliferation positive regulation of cell proliferation negative regulation of cardiac muscle cell apoptotic process fibroblast migration negative regulation of smooth muscle cell migration peptidyl-serine phosphorylation nerve development myelination in peripheral nervous system positive regulation of cell migration positive regulation of BMP signaling pathway myelin assembly regulation of actin cytoskeleton organization cell junction assembly substrate adhesion-dependent cell spreading positive regulation of phosphorylation extracellular fibril organization positive regulation of MAP kinase activity protein kinase B signaling negative regulation of neuron apoptotic process establishment or maintenance of epithelial cell apical/basal polarity positive regulation of myoblast differentiation positive regulation of osteoblast differentiation positive regulation of axon extension positive regulation of transcription, DNA-templated negative regulation of smooth muscle cell proliferation neuron projection morphogenesis positive regulation of dendrite morphogenesis protein heterooligomerization positive regulation of protein kinase B signaling platelet aggregation positive regulation of canonical Wnt signaling pathway negative regulation of neural precursor cell proliferation regulation of cell growth regulation of signal transduction Schwann cell development phosphorylation cell projection organization negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of axonogenesis
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