MA5-13773 targets Insulin Receptor alpha in IA applications and shows reactivity with Bovine, Human, Ovine, and Porcine samples.
The MA5-13773 immunogen is iM-9 lymphocytes followed by purified insulin receptor.
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a beta-alpha-alpha-beta configuration. The beta-subunit (95kDa) possesses a single transmembrane domain with tyrosine kinase activity, whereas the alpha-subunit (135kDa) is completely extracellular.
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Protein Aliases: CD220; HHF5; Insulin receptor; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha
Gene Aliases: BOS_7553; CD220; HHF5; INSR; ir; ir-A
UniProt ID: (Human) P06213