Fabgennix

IRF8 Polyclonal Antibody, FITC

Product Details

IRF8M-FITC

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-
ELISA (ELISA)	1:10,000	-
Immunoprecipitation (IP)	1:50-1:250	-

Product Specifications
Species Reactivity	Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide taken within amino acid region 350-400 on mouse Interferon Regulatory Factor 8 protein. View immunogen
Conjugate	FITC
Excitation/Emission Max	498/517 nm View spectra
Form	Liquid
Concentration	0.5-1.5 mg/mL
Purification	Affinity chromatography
Storage buffer	proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains	0.02% sodium azide
Storage conditions	-20° C, store in dark

Target Information

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ICSBP; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; IRF-8; transcription factor ICSBP

Gene Aliases: AI893568; ICSBP; Icsbp1; IRF-8; Irf8; Myls

UniProt ID: (Mouse) P23611

Entrez Gene ID: (Rat) 292060, (Mouse) 15900

Molecular Function: winged helix/forkhead transcription factor