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Invitrogen
ITPR3 Polyclonal Antibody
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Product Details
PA5-79544
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3 (70-95aa QYWKAKQTKQDKEKIADVVLLQKLQH).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human HepG2 whole cell. IHC: mouse intestine tissue, rat intestine tissue, human lung cancer tissue.
Target Information
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
Gene Aliases: CMT1J; IP3R; IP3R-3; IP3R3; IP3R3X; Itpr-3; ITPR3
UniProt ID: (Human) Q14573, (Mouse) P70227, (Rat) Q63269
Entrez Gene ID: (Human) 3710, (Mouse) 16440, (Rat) 25679
inositol hexakisphosphate binding
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
zinc ion binding
calcium-release channel activity
phosphatidylinositol binding
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
calcium ion transmembrane transporter activity
ligand-gated ion channel
ion transport
calcium ion transport
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
memory
calcium-mediated signaling
platelet activation
ion transmembrane transport
sensory perception of taste
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
release of sequestered calcium ion into cytosol
protein homotetramerization
response to calcium ion
calcium ion homeostasis
transmembrane transport
long-term synaptic potentiation
calcium ion transmembrane transport
transport
inositol phosphate-mediated signaling
protein homooligomerization
protein heterooligomerization
calcium ion transport into cytosol
cellular response to cAMP
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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