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Invitrogen

Insulin Polyclonal Antibody

View all (61) Insulin antibodies

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Insulin Polyclonal Antibody

Product Details

PA5149828

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-

Immunocytochemistry (ICC/IF)

5-20 µg/mL
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Insulin (INS) (Phe25-Ser54 and Gly90-Asn110 linked by GGGGS)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3715863

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ins; Insulin-1; Insulin-2

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Gene Aliases: AA986540; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; Mody; Mody4; proinsulin

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UniProt ID: (Mouse) P01325, (Mouse) P01326

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Entrez Gene ID: (Mouse) 16333, (Mouse) 16334

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Function(s)
protease binding insulin receptor binding hormone activity chaperone binding insulin-like growth factor receptor binding protein complex binding identical protein binding growth factor
Process(es)
carbohydrate metabolic process glucose metabolic process glucose transport negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity negative regulation of acute inflammatory response regulation of cellular amino acid metabolic process acute-phase response ER overload response G-protein coupled receptor signaling pathway activation of JUN kinase activity myoblast fusion positive regulation of cell proliferation insulin receptor signaling pathway regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling myotube differentiation lipid catabolic process regulation of transmembrane transporter activity activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization regulation of protein localization negative regulation of NAD(P)H oxidase activity wound healing negative regulation of protein catabolic process regulation of phosphorylation glucose homeostasis regulation of protein binding positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of proteolysis negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation regulation of protein secretion negative regulation of protein secretion positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of NF-kappaB transcription factor activity positive regulation of protein kinase B signaling fatty acid homeostasis canonical Wnt signaling pathway negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of protein localization to nucleus negative regulation of feeding behavior
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