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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||18 amino acid peptide near the center of human LAMTOR2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||20 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A recommended positive control is HepG2 cell lysate.
At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is not expected to cross-react with other LAMTOR family proteins.
The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling. This complex is involved in the regulation of late endosomal traffic and cellular proliferation and plays a role in cellular host defense against Salmonella infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ENDAP; Endosomal adaptor protein p14; HSPC003; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; late endosomal/lysosomal MP1 interacting protein; Late endosomal/lysosomal Mp1-interacting protein; MAPBP-interacting protein; MAPBPIP; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen activated protein binding protein interacting protein; mitogen-activated protein binding protein interacting protein; Mitogen-activated protein-binding protein-interacting protein; mitogen-activated protein-binding protein-interacting protein (MAPBPIP); Ragulator complex protein LAMTOR2; Ragulator2; roadblock domain containing 3; Roadblock domain-containing protein 3; ROBLD3
2010111E04Rik; AL022628; ENDAP; HSPC003; LAMTOR2; MAPBPIP; MAPKSP1AP; P14; Rab25; Ragulator2; ROBLD3