Immunogen sequence: FKSEDNNTED LKVTITKAGR KDDSTLCCWR HSTTEVSCQN QEYLFVYGGR SVVEPVLSDW HFLHVGTMAW VRIPVEGEVP EARHS
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 68%.
TYW4 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW4 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Leucine carboxyl methyltransferase 2; p21WAF1/CIP1 promoter-interacting protein; PPM2, TYW4; tRNA wybutosine-synthesizing protein 4; tRNA yW-synthesizing protein 4; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase; tRNA-Wybutosine-synthesizing protein 4; tRNA-yW synthesizing protein 4
Gene Aliases: KIAA0547; LCMT2; PPM2; TYW4
UniProt ID: (Human) O60294
Entrez Gene ID: (Human) 9836