Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: GPPEYQEKK LNDVTSFDYE CTTTDFVVHQ TLPYQSVSVD TFNSKNDVYV AIAQPSMENC MVLEWDHIEM NFRSYDNITG QSIVGCKAIL IDDQVFVVVA QLFGGSHIYK YDESWTKFVK FQDIEVSRIS KPNDIELFQI DDETFFVIAD SSKAGLSTVY KWNSKGFYSY QSLHEWFRDT DAEFVDIDGK SHLILSSRSQ VPIILQWNKS SKKFVPHGDI PNMEDVLAVK SFRMQNTLYL SLTRFIGDSR VMRWNSKQFV EIQALPSRGA MTLQPFSFKD NHYLALGSDY TFSQIYQWDK EKQLFKKFKE IYVQAPRSFT AVSTDRRDFF FASSFKGKTK IFEHIIVDLS L (196-545 aa encoded by BC101759)
The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Leucine-rich glioma-inactivated protein 2; Leucine-rich repeat LGI family member 2; leucine-rich repeat LGI family, member 2; leucine-rich, glioma inactivated 2; LGI1-like protein 2
Gene Aliases: KIAA1916; LGI2; LGIL2; mKIAA1916
UniProt ID: (Human) Q9NVK4, (Mouse) Q8K4Z0
Entrez Gene ID: (Human) 55203, (Mouse) 246316, (Rat) 305417
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support