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Invitrogen
LPIN1 Polyclonal Antibody
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Product Details
PA5-34566
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the carboxy terminus of human LPIN1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is K562 cell lysate.
PA5-34566 can be used with blocking peptide PEP-1609.
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P1796; Fatty liver dystrophy protein; KIAA0188; Lipin-1; Phosphatidate phosphatase LPIN1; unnamed protein product
Gene Aliases: 4631420P06; fld; Flde; KIAA0188; Lipin1; LPIN1; mKIAA0188; PAP1
UniProt ID: (Human) Q14693, (Mouse) Q91ZP3
Entrez Gene ID: (Human) 23175, (Rat) 313977, (Mouse) 14245
negative regulation of transcription from RNA polymerase II promoter
mitochondrial fission
lipid metabolic process
triglyceride mobilization
fatty acid catabolic process
dephosphorylation
triglyceride biosynthetic process
positive regulation of histone deacetylation
organ regeneration
ruffle organization
actin cytoskeleton reorganization
cellular response to insulin stimulus
regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
fat cell differentiation
fatty acid metabolic process
mitotic nuclear envelope disassembly
negative regulation of myelination
phosphatidylethanolamine metabolic process
phosphatidic acid metabolic process
positive regulation of cold-induced thermogenesis
negative regulation of phosphatidic acid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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