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Invitrogen
NGFR Monoclonal Antibody (MC192)
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Product Details
MA1-18417
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MC192
Immunogen
NGF receptor (aa 30-425).
Conjugate
Form
Lyophilized
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. The MC192 is supplied in lyophilised form from Protein G-purified hybridoma cell culture supernatants. The lyophilised antibody is stable when stored at 2-8 °C or -20 °C. After reconstitution undiluted aliquots should be kept at -20 °C for up to six months. For additional stability Glycerol (1:1) may be added after reconstitution. Repetitive freeze/thaw cycle should be avoided.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 ntr; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Aliases: LNGFR; Ngfr; p75; p75NTR; RNNGFRR; Tnfrsf16
UniProt ID: (Rat) P07174
Entrez Gene ID: (Rat) 24596
intracellular protein transport
apoptotic process
signal transduction
axon guidance
central nervous system development
response to wounding
regulation of gene expression
positive regulation of cell death
negative regulation of neuron projection development
programmed cell death
detection of temperature stimulus
sensory perception of pain
nerve development
hair follicle morphogenesis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
skin development
positive regulation of fibroblast proliferation
negative regulation of hair follicle development
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
negative regulation of cell death
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
positive regulation of apoptotic signaling pathway
regulation of glucose import in response to insulin stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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