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Invitrogen

RIP2 Monoclonal Antibody (Nick-1)

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RIP2 Monoclonal Antibody (Nick-1)

Product Details

MA1-25954

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

Nick-1

Immunogen

Recombinant fragment, corresponding to N terminal amino acids 1-322 of Human RIP2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

IgG fraction

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_795346

Product Specific Information

MA1-25954 detects RIP2 from human samples.

Target Information

RIPK2 is a serine/threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CARD domain protein; phosphorylated protein; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARDIAK; RIP-like kinase; EC 2.7.11.1; growth-in; growth-inhibiting gene 30; kinase RIPK2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; Receptor-interacting serine/threonine-protein kinase 2; RIP 2; RIP-2; RIP-like; RIP-like-interacting CLARP kinase; RIP2; serine/threonine kinase homolog; contains CARD motif; Tyrosine-protein kinase RIPK2; unnamed protein product; WUGSC:H_RG437L15.1

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Gene Aliases: CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2; UNQ277/PRO314/PRO34092

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UniProt ID: (Human) O43353

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Entrez Gene ID: (Human) 8767

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding kinase activity transferase activity LIM domain binding signaling adaptor activity identical protein binding protein homodimerization activity CARD domain binding caspase binding protein serine kinase activity
Process(es)
positive regulation of cytokine production positive regulation of cytokine-mediated signaling pathway adaptive immune response immune system process positive regulation of T-helper 1 type immune response apoptotic process inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling JNK cascade cytokine-mediated signaling pathway positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway CD4-positive, alpha-beta T cell proliferation p38MAPK cascade T cell proliferation defense response to bacterium regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response positive regulation of T-helper 1 cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-positive bacterium T cell receptor signaling pathway protein homooligomerization stress-activated MAPK cascade positive regulation of macrophage cytokine production ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway response to interleukin-1 response to interleukin-12 response to interleukin-18 cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to muramyl dipeptide regulation of primary metabolic process protein linear polyubiquitination xenophagy cell surface toll-like receptor signaling pathway positive regulation of protein K63-linked ubiquitination positive regulation of xenophagy positive regulation of CD4-positive, alpha-beta T cell proliferation
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