Search

  • お問い合わせ一覧​
  • クイックオーダー

Invitrogen

Presenilin 1 Monoclonal Antibody (APS 18)

Advanced Verification
1 Published Figure
6 References
View all (31) Presenilin 1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Presenilin 1 Monoclonal Antibody (APS 18)

Product Details

MA1-752

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50-1:500
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20 - 1:200
-

Immunocytochemistry (ICC/IF)

1:50 - 1:200
View 2 publications 2 publications

ELISA (ELISA)

1:1,000
-

Immunoprecipitation (IP)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

APS 18

Immunogen

Synthetic peptide corresponding to residues C S(313) K Y N A E S T E R E S Q D T V A E N D D G(334) of humen PS1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2170605

Product Specific Information

MA1-752 detects presenilin 1 protein (PS1) from mouse, rat, human, and nonhuman primate samples. No cross-reactivity is seen with presenilin 2.

MA1-752 has successfully been used in immuno-fluorescence, immunocytochemistry, Western blot, immunoprecipitation, and ELISA procedures. By Western blot, this antibody detects an ~18 kDa protein representing PS1 CT (C-terminus fragment) and the ~46 kDa full-length PS1 from transfected SH-SY5Y cells. In 4% paraformaldehyde fixed N2a cells, MA1-752 showed endogenous PS1 staining in the Golgi and cellular vesicles.

The MA1-752 immunogen is a synthetic peptide corresponding to residues C S(313) K Y N A E S T E R E S Q D T V A E N D D G(334) of humen PS1.

Target Information

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Alzheimer Disease 3; Minilin; Presenilin-1; presenilin1; Protein S182; PS-1; S182 protein; Senilin 1

View more View less

Gene Aliases: AD3; Ad3h; PS-1; PS1; PSEN1; PSNL1; S182

View more View less

UniProt ID: (Rat) P97887, (Mouse) P49769

View more View less

Entrez Gene ID: (Rat) 29192, (Mouse) 19164

View more View less

Function(s)
endopeptidase activity aspartic-type endopeptidase activity calcium channel activity protein binding beta-catenin binding peptidase activity PDZ domain binding cadherin binding hydrolase activity aspartic endopeptidase activity, intramembrane cleaving aspartic protease
Process(es)
autophagosome assembly negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity blood vessel development cell fate specification somitogenesis neuron migration positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of protein phosphorylation heart looping hematopoietic progenitor cell differentiation T cell activation involved in immune response myeloid leukocyte differentiation neural retina development negative regulation of protein kinase activity protein glycosylation proteolysis membrane protein ectodomain proteolysis calcium ion transport mitochondrial transport cellular calcium ion homeostasis autophagy cellular response to DNA damage stimulus response to oxidative stress negative regulation of epidermal growth factor-activated receptor activity regulation of epidermal growth factor-activated receptor activity Notch signaling pathway Notch receptor processing brain development heart development learning or memory memory post-embryonic development protein transport L-glutamate transport choline transport synaptic vesicle targeting single organismal cell-cell adhesion protein processing cerebral cortex cell migration Cajal-Retzius cell differentiation dorsal/ventral neural tube patterning cerebral cortex development neurogenesis neuron differentiation embryonic limb morphogenesis forebrain development positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis beta-amyloid formation segmentation intracellular signal transduction locomotion regulation of phosphorylation eye photoreceptor cell development amyloid precursor protein catabolic process myeloid dendritic cell differentiation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity regulation of protein binding positive regulation of MAP kinase activity negative regulation of neuron apoptotic process skin morphogenesis cellular protein metabolic process positive regulation of protein kinase activity regulation of synaptic plasticity thymus development neuron development skeletal system morphogenesis brain morphogenesis beta-amyloid metabolic process epithelial cell proliferation negative regulation of axonogenesis positive regulation of coagulation T cell receptor signaling pathway neuron apoptotic process negative regulation of ubiquitin-protein transferase activity smooth endoplasmic reticulum calcium ion homeostasis protein maturation regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway regulation of resting membrane potential calcium ion transmembrane transport negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway apoptotic process cell adhesion embryo development anagen positive regulation of transcription, DNA-templated positive regulation of dendritic spine development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support