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Invitrogen
CD34 Monoclonal Antibody (1H6), PE
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Product Details
MA1-81855
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog
Published species
Dog
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H6
Immunogen
Canine CD34 fusion protein.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 1% BSA, 5% sucrose
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark. Once reconstituted, this product has a shelf life of approx. 18 months.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti dog CD34 antibody, clone 1H6 recognizes the canine homologue of CD34, a glycosylated type 1 transmembrane protein of approximately 110 kDa (McSweeney et al. 1998) expressed on the cell suface of endothelial cells and haematopoietic stem cells.
Target Information
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD34; CD34 antigen; Hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein
Gene Aliases: CD34
UniProt ID: (Dog) Q28270
Entrez Gene ID: (Dog) 415130
tissue homeostasis
glomerular filtration
regulation of blood pressure
negative regulation of blood coagulation
negative regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
mesangial cell-matrix adhesion
positive regulation of odontogenesis
negative regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
leukocyte migration
positive regulation of transforming growth factor beta production
cell-cell adhesion
negative regulation of cellular response to heat
negative regulation of cellular response to hypoxia
negative regulation of neuron death
positive regulation of vasculogenesis
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