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Invitrogen
Progesterone Receptor Monoclonal Antibody (hPRa 6)
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Product Details
MA5-12653
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Rabbit
Published species
Chicken,
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
hPRa 6
Immunogen
Partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-12653 targets Progesterone Receptor in IF and IP applications and shows reactivity with Bovine, Chicken, Human, and Rabbit samples.
The MA5-12653 immunogen is partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nuclear receptor subfamily 3 group C member 3; pot. alt. progesterone receptor; putative; PR; Progesterone receptor; progesterone-receptor; steroid hormone receptor; unnamed protein product
Gene Aliases: NR3C3; PGR; PR
UniProt ID: (Rabbit) P06186, (Chicken) P07812, (Human) P06401
Entrez Gene ID: (Rabbit) 100009094, (Bovine) 100848466, (Chicken) 396198, (Human) 5241
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
zinc ion binding
enzyme binding
Hsp70 protein binding
chromatin DNA binding
sequence-specific DNA binding
Hsp90 protein binding
steroid hormone binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
receptor binding
steroid binding
protein binding
lipid binding
estrogen response element binding
identical protein binding
metal ion binding
ATPase binding
sequence-specific double-stranded DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
intracellular steroid hormone receptor signaling pathway
response to progesterone
steroid hormone mediated signaling pathway
response to estrogen
ovulation from ovarian follicle
epithelial cell maturation
glandular epithelial cell maturation
signal transduction
cell-cell signaling
positive regulation of gene expression
negative regulation of gene expression
mammary gland development
paracrine signaling
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
regulation of epithelial cell proliferation
progesterone receptor signaling pathway
maintenance of protein location in nucleus
tertiary branching involved in mammary gland duct morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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