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Invitrogen

PSD-95 Monoclonal Antibody (6G6), FITC

View all (53) PSD-95 antibodies

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Product Details

MA5-45138

Applications
Tested Dilution
Publications

Western Blot (WB)

1:250
-

Immunohistochemistry (IHC)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

6G6

Immunogen

Recombinant rat PSD-95

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G, Protein A

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.2, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931592

Product Specific Information

1 µg/mL was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.|Detects approximately 100kDa. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at approximately 75kDa and 50kDa in rat and mouse samples.

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: discs large homolog 4; Disks large homolog 4; FLJ97752; FLJ98574; post synaptic density; post-synaptic density protein 95; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15; unnamed protein product

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Gene Aliases: DLG4; Dlgh4; MRD62; PSD-95; PSD95; SAP-90; SAP90; SAP90A

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UniProt ID: (Human) P78352, (Rat) P31016, (Mouse) Q62108

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Entrez Gene ID: (Bovine) 100137840, (Human) 1742, (Rat) 29495, (Mouse) 13385

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Function(s)
protein binding kinase binding protein kinase binding protein phosphatase binding PDZ domain binding protein binding, bridging beta-1 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding acetylcholine receptor binding ionotropic glutamate receptor binding macromolecular complex binding neuroligin family protein binding scaffold protein binding guanylate kinase activity receptor binding protein C-terminus binding protein complex binding glutamate receptor binding structural molecule activity neurexin family protein binding scaffold/adaptor protein
Process(es)
negative regulation of receptor internalization signal transduction positive regulation of cytosolic calcium ion concentration chemical synaptic transmission nervous system development learning synaptic vesicle maturation social behavior protein localization to synapse locomotory exploration behavior cellular response to potassium ion establishment of protein localization establishment or maintenance of epithelial cell apical/basal polarity regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance dendritic spine morphogenesis protein-containing complex assembly vocalization behavior AMPA glutamate receptor clustering receptor localization to synapse cell-cell adhesion NMDA selective glutamate receptor signaling pathway regulation of postsynaptic membrane neurotransmitter receptor levels neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of neuron projection arborization positive regulation of excitatory postsynaptic potential regulation of grooming behavior protein complex assembly neuronal ion channel clustering nucleotide phosphorylation regulation of N-methyl-D-aspartate selective glutamate receptor activity locomotory behavior response to cocaine regulation of neuronal synaptic plasticity
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