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MINA Polyclonal Antibody
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FIGURE: 1 / 3
MINA Antibody (600-401-CU6) in ICC/IF
Immunofluorescence Microscopy of MINA antibody. Tissue: Mouse heart tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: MINA antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: MINA is nuclear. Staining: MINA as red fluorescent signal.
Product Details
600-401-CU6
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-MINA antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the N-terminus of human MINA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; Histone lysine demethylase MINA; MDIG2; cell cycle regulatory protein; mina; mineral dust induced gene; mineral dust induced gene protein; mineral dust-induced gene; Mineral dust-induced gene protein; mineral dust-induced protein; mina53; nucleolar protein; NO52; ribosomal oxygenase 2; RIOX2; JMJD10; MYC induced nuclear antigen; MYC-induced nuclear antigen; MYC-induced nuclear antigen 53; myc-induced nuclear antigen, 53 kDa; Nucleolar protein 52; Protein mina53; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; ROX; unnamed protein product
Gene Aliases: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204; JMJD10; MDIG; MINA; MINA53; NO52; RIOX2; ROX
UniProt ID: (Mouse) Q8CD15, (Human) Q8IUF8
Entrez Gene ID: (Mouse) 67014, (Human) 84864
sulfonate dioxygenase activity
transcriptional repressor activity, RNA polymerase II transcription factor binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
transcription corepressor activity
protein binding
histone demethylase activity
histone demethylase activity (H3-K4 specific)
peptidyl-histidine dioxygenase activity
identical protein binding
histone demethylase activity (H3-K36 specific)
chromatin remodeling
ribosome biogenesis
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell proliferation
regulation of cell proliferation
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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