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Proteintech
MIP-3-beta Polyclonal Antibody
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Product Details
13397-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MIP-3-beta Fusion Protein Ag4200 (1-98 aa encoded by BC027968)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MALLLALSL LVLWTSPAPT LSGTNDAEDC CLSVTQKPIP GYIVRNFHYL LIKDGCRVPA VVFTTLRGRQ LCAPPDQPWV ERIIQRLQRT SAKMKRRSS (1-98 aa encoded by BC027968)
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta chemokine exodus-3; Beta-chemokine exodus-3; C-C motif chemokine; C-C motif chemokine 19; CC chemokine ligand 19; chemokine (C-C motif) ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; M-MIP-3-beta; Macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP-3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; Small-inducible cytokine A19
Gene Aliases: CCL19; CKb11; ELC; MIP-3b; MIP3B; SCYA19
UniProt ID: (Human) Q99731
Entrez Gene ID: (Human) 6363
establishment of T cell polarity
immunological synapse formation
dendritic cell chemotaxis
myeloid dendritic cell chemotaxis
monocyte chemotaxis
positive regulation of dendritic cell antigen processing and presentation
cellular calcium ion homeostasis
inflammatory response
immune response
cell communication
G-protein coupled receptor signaling pathway
activation of JUN kinase activity
response to virus
positive regulation of glycoprotein biosynthetic process
T cell costimulation
positive regulation of interleukin-12 production
positive regulation of tumor necrosis factor production
response to prostaglandin E
positive regulation of T cell proliferation
positive regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of T-helper 1 cell differentiation
positive regulation of endocytosis
positive regulation of protein kinase activity
positive regulation of JNK cascade
lymphocyte chemotaxis
positive regulation of receptor-mediated endocytosis
cell maturation
positive regulation of interleukin-1 beta secretion
positive regulation of chemotaxis
release of sequestered calcium ion into cytosol
positive regulation of protein kinase B signaling
regulation of cell projection assembly
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
response to nitric oxide
interleukin-12 secretion
positive regulation of neutrophil chemotaxis
mature conventional dendritic cell differentiation
cellular response to virus
negative regulation of leukocyte apoptotic process
positive regulation of cell motility
positive regulation of dendritic cell dendrite assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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