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Proteintech
MRPL12 Polyclonal Antibody
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Product Details
14795-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MRPL12 Fusion Protein Ag6504 (1-198 aa encoded by BC002344)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody reacts specifically with 21 kDa MRPL12 protein.
Immunogen sequence: MLPAAARPL WGPCLGLRAA AFRLARRQVP CVCAVRHMRS SGHQRCEALA GAPLDNAPKE YPPKIQQLVQ DIASLTLLEI SDLNELLKKT LKIQDVGLVP MGGVMSGAVP AAAAQEAVEE DIPIAKERTH FTVRLTEAKP VDKVKLIKEI KNYIQGINLV QAKKLVESLP QEIKANVAKA EAEKIKAALE AVGGTVVLE (1-198 aa encoded by BC002344 )
Target Information
MRPL12 (mitochondrial ribosomal protein L12), also referred to as 5c5-2, L12mt, MRPL7 or RPML12, is a mammalian mitochondrial ribosomal protein that is involved in protein synthesis within the mitochondrion. MRPL12 is enhanced in growth-stimulated cells as a result of transcriptional activation, suggesting that it may function as a translational regulator of mitochondrial mRNAs. Impairment of MRPL12 leads to reduction in cell growth rate, decreased mitochondrial ATP production and abolition of mitochondrial oxidative phosphorylation. MRPL12 is cleaved during its translocation across the mitochondrial membrane and it exists as dimers that bind the large ribosomal subunit. MRPL12 is 198 amino acids in length, belongs to the ribosomal protein L12P family and is highly expressed in the colon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 39S ribosomal protein L12, mitochondrial; 5c5-2; FLJ60124; L12mt; Large ribosomal subunit protein bL12m; MGC8610; mitochondrial large ribosomal subunit protein bL12m; MRP-L12; ribosomal protein, mitochondrial, L12
Gene Aliases: 0610034O11Rik; 1500031N16Rik; 5c5-2; bL12m; L12mt; MRP-L12; MRP-L31/34; MRPL12; MRPL7; MRPL7/L12; Rpm12; RPML12
UniProt ID: (Human) P52815, (Mouse) Q9DB15
Entrez Gene ID: (Human) 6182, (Mouse) 56282, (Rat) 303746
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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