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Invitrogen
TIMP1 Monoclonal Antibody (102D1)
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FIGURE: 1 / 9
TIMP1 Antibody (MS608PABX) in ICC/IF
Immunofluorescent analysis of TIMP-1 was performed using 70% confluent log phase MDA-MB-231 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with TIMP-1 (102D1) Mouse Monoclonal Antibody (Product # MS608PABX) at 1:250 dilution in0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate ... View More
Product Details
MS608PABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
102D1
Immunogen
Recombinant human TIMP-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C
RRID
Product Specific Information
MS608PABX targets TIMP-1 in immunohistochemistry and western blot applications and shows reactivity with human samples.
The MS608PABX immunogen is recombinant human TIMP-1.
MS608PABX detects TIMP-1 which has a predicted molecular weight of approximately 21 kDa.
Target Information
TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor. TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16. It also functions as a growth factor that regulates cell differenation, migration, and cell death. TIMP1 activates cellular signaling cascades via CD63 and ITGB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Collagenase inhibitor; EPA; epididymis secretory sperm binding protein; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; Metalloproteinase inhibitor; Metalloproteinase inhibitor 1; MMP inhibitor; prefibroblast collagenase inhibitor; RP1-230G1.3; TIMP; TIMP 1; TIMP-1; TIMP1; Tissue inhibitor of metalloproteinases 1; unnamed protein product
Gene Aliases: CLGI; EPA; EPO; HCI; TIMP; TIMP-1; TIMP1
UniProt ID: (Human) P01033
Entrez Gene ID: (Human) 7076
connective tissue replacement involved in inflammatory response wound healing
signal transduction
positive regulation of cell proliferation
response to hormone
negative regulation of endopeptidase activity
response to cytokine
negative regulation of apoptotic process
negative regulation of catalytic activity
response to peptide hormone
negative regulation of membrane protein ectodomain proteolysis
cartilage development
cellular response to UV-A
negative regulation of trophoblast cell migration
cellular response to peptide
negative regulation of metallopeptidase activity
regulation of integrin-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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