Drosophila,muscle segment (msh) homolog 1,homeo domain encoding gene,inhibiting MYOD1 expression,highly expressed in dental mesenchyme during critical bud stage,involved in epithelial-mesenchymal signaling in many organs,and in the pathogenesis of cleft lip and palate,interacting with MSX2 in mouse limb bud patterning .This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition.Tissue specificity: Expressed in the developing nail bed mesenchyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homeo box, msh-like 1; homeo box, msh-like 2; homeobox 7; Homeobox protein Hox-7; Homeobox protein Hox-8; Homeobox protein Hox-8-1; Homeobox protein MSX-1; Homeobox protein MSX-2; homeobox, msh-like 1; homeobox, msh-like 2; Hox-7.1; hox-8.1; msh homeo box 1; msh homeo box 2; msh homeo box homolog 2; Msh homeobox 1-like protein; msh homeobox homolog 1; msh homeobox homolog 2; muscle-segment homeobox
Gene Aliases: AA675338; AI324650; BB122635; CRS2; ECTD3; FPP; Hox-7; Hox-8; Hox-8.1; HOX7; Hox7.1; HOX8; Hox8.1; HYD1; MSH; Msx-2; MSX1; MSX2; PFM; PFM1; STHAG1
Molecular Function: homeodomain transcription factor