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Invitrogen
NALP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is U937 cell lysate.
PA5-20005 can be used with blocking peptide PEP-0308.
Target Information
NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apaf-1/Ced-4 family apoptosis regulator; CARD7; caspase recruitment domain protein 7; caspase recruitment domain-containing protein 7; contains NACHT, LRR and PYD domains; death effector filament-forming Ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; unnamed protein product
Gene Aliases: AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; JRRP; MSPC; NAC; NALP1; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000
Entrez Gene ID: (Human) 22861
double-stranded DNA binding
double-stranded RNA binding
endopeptidase activity
protein binding
ATP binding
cysteine-type endopeptidase activator activity involved in apoptotic process
ATPase activity
enzyme binding
protein domain specific binding
signaling adaptor activity
pattern recognition receptor activity
cysteine-type endopeptidase activator activity
molecular condensate scaffold activity
activation of innate immune response
pattern recognition receptor signaling pathway
apoptotic process
inflammatory response
signal transduction
response to muramyl dipeptide
positive regulation of interleukin-1 beta production
defense response to bacterium
regulation of apoptotic process
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
protein homooligomerization
neuron apoptotic process
defense response to virus
pyroptosis
cellular response to UV-B
intrinsic apoptotic signaling pathway
self proteolysis
antiviral innate immune response
canonical inflammasome complex assembly
NLRP1 inflammasome complex assembly
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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