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Invitrogen
NMDAR2D Polyclonal Antibody
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FIGURE: 1 / 1
NMDAR2D Antibody (PA5-87624) in WB
Western blot analysis of NMDAR2D in extracts of various cell lines. Samples were incubated with NMDAR2D Polyclonal antibody (Product # PA5-87624) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-87624
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.84 mg/mL
Amount
184 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GAQALLRDYG FLPELGHDCR AQNRTHRGES LHRYFMNITW DNRDYSFNED GFLVNPSLVV ISLTRDRTWE VVGSWEQQTL RLKYPLWSRY GRFLQPVDDT QHLTVATLEE RPFVIVEPAD PISGTCIRDS VPCRSQLNRT HSPPPDAPRP E; Positive Samples: SH-SY5Y, Mouse liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EB11; estrogen receptor binding CpG island; GluN2D; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor; Glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D
Gene Aliases: DEE46; EB11; EIEE46; GluN2D; GRIN2D; NMDAR2D; NR2D
UniProt ID: (Human) O15399
Entrez Gene ID: (Human) 2906
ionotropic glutamate receptor activity
NMDA glutamate receptor activity
ion channel activity
cation channel activity
protein binding
ligand-gated ion channel activity
glutamate binding
voltage-gated cation channel activity
glutamate-gated calcium ion channel activity
signaling receptor activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
startle response
ion transport
brain development
adult locomotory behavior
calcium-mediated signaling
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of sensory perception of pain
positive regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane import into cytosol
cation transmembrane transport
excitatory chemical synaptic transmission
regulation of presynaptic membrane potential
regulation of cation transmembrane transport
cellular response to L-glutamate
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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