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Alomone Labs, LTD
P2X2 Receptor (extracellular) Polyclonal Antibody
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FIGURE: 1 / 2
P2X2 Receptor (extracellular) Antibody (APR-025-200UL) in ICC/IF
Expression of P2RX2 in rat PC12 cells - Cell surface detection of P2RX2 in intact living rat pheochromocytoma cell line (PC12). A. Extracellular staining of cells with Anti-P2X2 Receptor (extracellular) Antibody (#APR-025), (1:50) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody . B. Staining of cells with DAPI used as the counterstain. C. Merged images of A and B.
Product Details
APR-025-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KSDYLKHSTFDQDS, corresponding to amino acid residues 207-220 of rat P2X2 with replacement of cysteine 214 (C214) with serine (*S), Extracellular
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Amount
170 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
P2rx2 are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. P2rx2 functions as a ligand-gated ion channel and binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for P2rx2. P2rx2 is involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, P2rx2 regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. P2rx2 also mediates synaptic transmission between neurons and from neurons to smooth muscle. Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41 and Dfna41 Nonsyndromic Hearing Loss And Deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; MGC129601; P2X purinoceptor 2; P2X2; Purinergic receptor
Gene Aliases: P2rx2; P2X2; P2X2a
UniProt ID: (Rat) P49653, (Mouse) Q8K3P1
Entrez Gene ID: (Rat) 114115, (Mouse) 231602
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ion channel activity
copper ion binding
protein binding
ATP binding
drug binding
zinc ion binding
ligand-gated ion channel activity
nickel cation binding
phosphatidylinositol binding
identical protein binding
mercury ion binding
cadmium ion binding
cobalt ion binding
ligand-gated ion channel
response to hypoxia
detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
cation transport
chemical synaptic transmission
neuromuscular synaptic transmission
neuromuscular junction development
sensory perception of sound
response to carbohydrate
response to organic substance
urinary bladder smooth muscle contraction
neuronal action potential
peristalsis
response to ATP
ion transmembrane transport
purinergic nucleotide receptor signaling pathway
behavioral response to pain
skeletal muscle fiber development
sensory perception of taste
protein homooligomerization
protein heterooligomerization
cation transmembrane transport
transport
ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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