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Invitrogen
alpha-2c Adrenergic Receptor Polyclonal Antibody
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Product Details
PA1-4518
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to internal residues of the alpha-2c Adrenergic Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-4518 detects alpha-2c AR in human, rat, and mouse samples.
PA1-4518 has been successfully used in Western blot and Immunohistochemistry procedures.
The PA1-4518 immunogen is a synthetic peptide corresponding to internal residues of the alpha-2c Adrenergic Receptor.
Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid repeated freeze-thaw cycles.
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adra 2c; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; Alpha 2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; kidney alpha-2-adrenergic receptor; subtype alpha2-C4
Gene Aliases: [a]2C; Adra-2c; ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; alpha2-C4; alpha2C; ALPHA2CAR
UniProt ID: (Human) P18825, (Mouse) Q01337, (Rat) P22086
Entrez Gene ID: (Human) 152, (Mouse) 11553, (Rat) 24175
G-protein coupled receptor activity
adrenergic receptor activity
alpha2-adrenergic receptor activity
guanyl-nucleotide exchange factor activity
protein binding
alpha-2A adrenergic receptor binding
protein homodimerization activity
protein heterodimerization activity
epinephrine binding
signal transducer activity
G-protein coupled receptor
regulation of smooth muscle contraction
signal transduction
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
negative regulation of epinephrine secretion
positive regulation of MAPK cascade
positive regulation of neuron differentiation
negative regulation of insulin secretion
positive regulation of protein kinase B signaling
adrenergic receptor signaling pathway
negative regulation of adenylate cyclase activity
female pregnancy
activation of protein kinase B activity
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of vasoconstriction
regulation of sensory perception of pain
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of uterine smooth muscle contraction
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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