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Invitrogen
NALP2 Polyclonal Antibody
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Product Details
PA5-29196
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human NALP2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, H1299, HeLa, Molt-4.
Predicted reactivity: Rhesus Monkey (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1-b-processing activity and is thought to function as a modulator of NF-kappa-B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: contains NACHT, LRR and PYD domains; FLJ20510; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD domains-containing protein 2; NBS1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PYPAF2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; unnamed protein product
Gene Aliases: CLR19.9; NALP2; NBS1; NLRP2; OZEMA18; PAN1; PYPAF2
UniProt ID: (Human) Q9NX02
Entrez Gene ID: (Human) 55655
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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