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Invitrogen
TOB2 Polyclonal Antibody
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Product Details
PA5-64968
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human TOB2. Recombinant protein control fragment (Product #RP-105739).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PELDKEIKSSF NPDAQVFVPI GSQDSSLSNS PSPSFGQSPS PTFIPRSAQP ITFTTASFAA TKFGSTKMKK GGGAASGGGV ASSGAGGQQP PQQPRMARSP TNSLLKHKSL SLSMHSLNFI TANPAPQSQL SPNAKEFVYN GGGSPSLFFD AADGQGSGTP GPFGGSGAGT CNSS
Highest antigen sequence identity to the following orthologs - mouse 86%, rat 88%.
Target Information
TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein Tob2; Protein Tob4; TOB2; Transducer of erbB-2 2
Gene Aliases: APRO5; KIAA1663; TOB2; TOB4; TOBL; TROB2
UniProt ID: (Human) Q14106
Entrez Gene ID: (Human) 10766
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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