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CRP Polyclonal Antibody
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FIGURE: 1 / 5
CRP Antibody (PA5-79070) in IHC (P)
Immunohistochemistry analysis of CRP on paraffin-embedded rat cerebellum tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with CRP polyclonal antibody (Product# PA5-79070) with a dilution of 2 µg/mL (overnight at 4°C), followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Development w... View More
Product Details
PA5-79070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived rat C Reactive Protein recombinant protein (Position: H20-S230).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat heart tissue, rat lung tissue. IHC: rat cerebellum tissue, rat lung tissue, rat spleen tissue.
Target Information
CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c reactive; C-reactive protein; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family; C-reactive protein, petaxin related; CRP1; CSRP; CYRP; D1S181E; DKFZp686M148; DKFZp686M149; MGC149895; MGC88244; RP11-419N10.4
Gene Aliases: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; Ba2-693; Crp; Ptx1
UniProt ID: (Rat) P48199
Entrez Gene ID: (Rat) 25419
response to hypoxia
acute-phase response
complement activation, classical pathway
aging
response to radiation
response to lead ion
positive regulation of gene expression
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
regulation of low-density lipoprotein particle clearance
response to estradiol
negative regulation of superoxide anion generation
positive regulation of superoxide anion generation
response to testosterone
wound healing
positive regulation of nitric oxide biosynthetic process
response to ethanol
negative regulation of vasodilation
protein polymerization
cellular response to calcium ion
cellular response to interleukin-6
cellular response to nitric oxide
positive regulation of dendrite development
regulation of interleukin-8 secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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