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Invitrogen
Prolactin Receptor Polyclonal Antibody
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FIGURE: 1 / 1
Prolactin Receptor Antibody (PA5-87960) in WB
Western blot analysis of Prolactin Receptor in extracts of various cell lines. Samples were incubated with Prolactin Receptor Polyclonal antibody (Product # PA5-87960) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-87960
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human Prolactin Receptor (NP_0009401)
Conjugate
Form
Liquid
Concentration
2.08 mg/mL
Amount
208 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QLPPGKPEIF KCRSPNKETF TCWWRPGTDG GLPTNYSLTY HREGETLMHE CPDYITGGPN SCHFGKQYTS MWRTYIMMVN ATNQMGSSFS DELYVDVTYI VQPDPPLELA VEVKQPEDRK PYLWIKWSPP TLIDLKTGWF TLLYEIRLKP EKAAEWEIHF AGQQTEFKIL SLHPGQKYLV QVRCKPDHGY WSAWSPATFI QIPSDFTMND; Positive Samples: 293T, MCF-7, Mouse ovary; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine receptor; cytokine receptor; PRLRSFA; cytokine receptor; PRLRSFB; delta-S1 PRLr; hPRL receptor; Lactogen receptor; Prl R; PRL-R; Prolactin receptor; prolactin receptor related sequence 1; secreted prolactin binding protein; unnamed protein product
Gene Aliases: AI987712; HPRL; hPRLrI; MFAB; Pr-1; Pr-3; PRLR; Prlr-rs1; RATPRLR; RI-PRLR
UniProt ID: (Human) P16471, (Rat) P05710, (Mouse) Q08501
Entrez Gene ID: (Human) 5618, (Rat) 24684, (Mouse) 19116
steroid biosynthetic process
activation of transmembrane receptor protein tyrosine kinase activity
JAK-STAT cascade
embryo implantation
lactation
positive regulation of cell proliferation
response to bacterium
cytokine-mediated signaling pathway
regulation of cell adhesion
regulation of epithelial cell differentiation
positive regulation of B cell proliferation
prolactin signaling pathway
activation of Janus kinase activity
negative regulation of apoptotic process
mammary gland epithelial cell differentiation
prostate gland growth
mammary gland alveolus development
mammary gland epithelium development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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