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Invitrogen
alpha-1 Antitrypsin Polyclonal Antibody
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Product Details
PA5-88574
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Amount
67 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EDPQGDAAQK TDTSHHDQDH PTFNKITPNL AEFAFSLYRQ LAHQSNSTNI FFSPVSIATA FAMLSLGTKA DTHDEILEGL NFNLTEIPEA QIHEGFQELL RTLNQPDSQL QLTTGNGLFL SEGLKLVDKF LEDVKKLYHS EAFTVNFGDT EEAKKQINDY VEKGTQGKIV DLVKELDRDT VFALVNYIFF KGKWERPFEV KDTEEEDFHV DQVTTVKVPM MKRLGMFNIQ HCKKLSSWVL LMKYLGNATA IFFLPDEGKL QHLENELTHD IITKFLENED RRSASLHLPK L; Positive Samples: SW480, HT-29, Mouse lung; Cellular Location: Endoplasmic reticulum, extracellular matrix, extracellular space
Target Information
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a-1 AT; a1-antitrypsin; AAT; alpha 1 antitrypsin; alpha-1 antitrypsin; Alpha-1 protease inhibitor; Alpha-1 protease inhibitor 1; alpha-1 proteinase inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (alpha-1-AT); alpha-1-antitrypsin (protease inhibitor); Alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; alpha-1-protease inhibitor; Alpha-1-proteinase inhibitor; anti-elastase; Digestive Zymogen; epididymis secretory sperm binding protein; MGC23330; MGC9222; protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; Protease Serine 1; proteolytic enzyme inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1a; Serine Protease 1; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; serine protease inhibitor alpha 1; Serpin A1; Serpin A1a; serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1 isoform SERPINA1_1; serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1 isoform SERPINA1_2; serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; TRP1; TRY1; unnamed protein product
Gene Aliases: A1A; A1AT; AAT; Aat-2; Aat2; alpha1AT; Dom1; nNIF; PI; PI1; PRO0684; PRO2209; PRO2275; SERPINA1; Serpina1a; Spi1; Spi1-1; Spi1-3
UniProt ID: (Human) P01009, (Rat) P17475, (Mouse) P07758
Entrez Gene ID: (Human) 5265, (Rat) 24648, (Mouse) 20700
acute-phase response
blood coagulation
hemostasis
response to hypoxia
inflammatory response
response to inorganic substance
response to lead ion
response to organic cyclic compound
response to estradiol
response to lipopolysaccharide
response to methanol
response to triglyceride
response to cytokine
response to chromate
negative regulation of serine-type endopeptidase activity
protein N-linked glycosylation
negative regulation of peptidase activity
negative regulation of endopeptidase activity
response to peptide hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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