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Invitrogen

PDGF-BB Polyclonal Antibody

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PDGF-BB Polyclonal Antibody

Product Details

PA5-88272

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.58 mg/mL

Amount

258 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804792

Product Specific Information

Positive Samples: SW480, MCF7, Mouse skeletal muscle

Immunogen sequence: QCRPTQVQLR PVQVRKIEIV RKKPIFKKAT VTLEDHLACK CETVAAARPV TRSPGGSQEQ RAKTPQTRVT IRTVRVRRPP KGKHRKFKHT HDKTALKETL GA

Target Information

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: becaplermin; epididymis secretory sperm binding protein; FLJ12858; H-PDGF-BB; orf 2; pdgf protein; PDGF subunit B; PDGF, B chain; PDGF-2; PDGFB; platelet derived growth factor, B polypeptide; platelet-derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); Proto-oncogene c-Sis; unnamed protein product

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Gene Aliases: c-sis; IBGC5; PDGF-2; PDGF2; PDGFB; SIS; SSV

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UniProt ID: (Human) P01127, (Rat) Q05028

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Entrez Gene ID: (Human) 5155, (Rat) 24628

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Function(s)
platelet-derived growth factor receptor binding protein binding collagen binding growth factor activity superoxide-generating NADPH oxidase activator activity chemoattractant activity identical protein binding protein homodimerization activity protein heterodimerization activity receptor agonist activity platelet-derived growth factor binding receptor binding growth factor
Process(es)
angiogenesis embryonic placenta development positive regulation of endothelial cell proliferation monocyte chemotaxis positive regulation of glomerular filtration protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway heart development positive regulation of cell proliferation response to wounding gene expression regulation of gene expression negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation positive regulation of macromolecule biosynthetic process positive regulation of gene expression negative regulation of gene expression positive regulation of cell-substrate adhesion smooth muscle adaptation positive regulation of smooth muscle cell migration peptidyl-tyrosine phosphorylation hemopoiesis positive regulation of cell migration positive regulation of protein autophosphorylation intracellular signal transduction interleukin-18-mediated signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus paracrine signaling positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation positive chemotaxis positive regulation of chemotaxis regulation of multicellular organismal process positive regulation of cell division positive regulation of protein kinase B signaling cell chemotaxis positive regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to mycophenolic acid positive regulation of glomerular mesangial cell proliferation metanephric glomerular mesangial cell development reactive oxygen species metabolic process positive regulation of calcium ion import positive regulation of hyaluronan biosynthetic process positive regulation of intracellular signal transduction negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration negative regulation of vascular smooth muscle cell differentiation positive regulation of vascular smooth muscle cell dedifferentiation positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process positive regulation of metanephric mesenchymal cell migration response to hypoxia DNA replication substrate-dependent cell migration blood coagulation response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling response to organic cyclic compound cell growth peptidyl-serine phosphorylation cell projection assembly actin cytoskeleton organization negative regulation of cell migration activation of protein kinase activity activation of protein kinase B activity response to estradiol response to insulin wound healing regulation of cell proliferation response to drug positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of DNA replication positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of mitotic cell cycle, embryonic blood vessel morphogenesis regulation of peptidyl-tyrosine phosphorylation positive regulation of peptidyl-tyrosine phosphorylation branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis positive regulation of protein tyrosine kinase activity metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular endothelium development
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