|Immunocytochemistry (ICC)||10 µg/ml|
|Western Blot (WB)||1 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
In Western blot applications, this antibody detects a band at ~21kDa. A suggested positive control is A431 cell lysate.
PA5-19980 can be used with blocking peptide PEP-0104.
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1110017A08Rik; 1110017A08Rik, KCP1, KRTCAP1, PIGPC1, THW; KCP-1; keratinocyte associated protein 1; Keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; p53 apoptosis-associated target; P53-induced protein PIGPC1; Transmembrane protein THW
Gene Aliases: dJ496H19.1; KCP1; KRTCAP1; PERP; PIGPC1; THW
UniProt ID: (Human) Q96FX8
Entrez Gene ID: (Human) 64065
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.