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Invitrogen
PIK3C2A Polyclonal Antibody
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Product Details
PA5-114770
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PIK3C2A(Accession O00443), corresponding to amino acid residues D1588-R1638.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PI 3 Kinase Class 2A.
Target Information
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enyzmes have been linked to diverse, receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C2-containing phosphatidylinositol kinase; Cpk-m; DKFZp686L193; MGC142218; p170; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Phosphoinositide 3-kinase-C2-alpha; phosphoinositide-3-kinase, class 2, alpha polypeptide; PI3K-C2-alpha; pi3kc2a; ptdIns-3-kinase C2 subunit alpha
Gene Aliases: CPK; Cpk-m; PI3-K-C2(ALPHA); PI3-K-C2A; PI3K-C2-alpha; PI3K-C2alpha; PI3KC2; PIK3C2A
UniProt ID: (Human) O00443, (Mouse) Q61194
Entrez Gene ID: (Human) 5286, (Mouse) 18704
ATP binding
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol 3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
phosphatidylinositol binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
phosphatidylinositol biosynthetic process
exocytosis
endocytosis
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
vascular smooth muscle contraction
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
clathrin coat assembly
adaptive immune response
protein phosphorylation
inflammatory response
phosphatidylinositol 3-kinase signaling
phosphorylation
platelet activation
innate immune response
cell chemotaxis
negative regulation of zinc ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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