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This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.
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Protein Aliases: 40 kDa peptidyl-prolyl cis-trans isomerase; 40 kDa peptidyl-prolyl cis-trans isomerase D; cyclophilin 40; cyclophilin D; Cyclophilin-40; Cyclophilin-related protein; Cyp 40; Cyp D; CYP-40; cytoplasmic cyclophilin D; EC 188.8.131.52; MGC33096; Peptidyl-prolyl cis-trans isomerase D; PPIase D; rotamase; Rotamase D; testicular tissue protein Li 147
Gene Aliases: 4930564J03Rik; CYP-40; CYP40; CYPD; PPID; Ppidl; Ppif
Molecular Function: isomerase