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Bioss
PRDX5 Polyclonal Antibody
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Product Details
BS-7356R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PRDX5, amino acids 141-214.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alu co-repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; epididymis secretory protein Li 55; hAOEB166; alkyl hydroperoxide reductase; thioredoxin peroxidase; Liver tissue 2D-page spot 2D-0014IV; Liver tissue 2D-page spot 71B; peroxiredoxin 6; Peroxiredoxin V; Peroxiredoxin-5, mitochondrial; Peroxisomal antioxidant enzyme; peroxisomal membrane protein 20; PLP; PMP20; PRDX5; Prx-V; Prx5; Thioredoxin peroxidase PMP20; thioredoxin reductase; Thioredoxin-dependent peroxiredoxin 5; TPx type VI
Gene Aliases: ACR1; AOEB166; AOPP; B166; HEL-S-55; PLP; PMP20; PRDX5; PRDX6; prx-V; PRXV; SBBI10
UniProt ID: (Human) P30044, (Mouse) P99029, (Rat) Q9R063
Entrez Gene ID: (Human) 25824, (Mouse) 54683, (Rat) 113898
RNA polymerase III regulatory region DNA binding
peroxidase activity
receptor binding
protein binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxynitrite reductase activity
thioredoxin-dependent peroxiredoxin activity
protein dimerization activity
peroxiredoxin activity
oxidoreductase
inflammatory response
response to oxidative stress
negative regulation of transcription from RNA polymerase III promoter
positive regulation of collagen biosynthetic process
cellular response to oxidative stress
cellular response to reactive oxygen species
hydrogen peroxide catabolic process
negative regulation of apoptotic process
cell redox homeostasis
negative regulation of oxidoreductase activity
regulation of apoptosis involved in tissue homeostasis
cellular oxidant detoxification
reactive nitrogen species metabolic process
apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
oxidation-reduction process
NADPH oxidation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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