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PRLR Polyclonal Antibody
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FIGURE: 1 / 3
PRLR Antibody (BS-6445R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with PRLR Polyclonal Antibody (bs-6445R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining.
Product Details
BS-6445R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Prolactin Receptor, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytokine receptor; cytokine receptor; PRLRSFA; cytokine receptor; PRLRSFB; delta-S1 PRLr; hPRL receptor; Lactogen receptor; Prl R; PRL-R; Prolactin receptor; prolactin receptor related sequence 1; secreted prolactin binding protein; unnamed protein product
Gene Aliases: AI987712; HPRL; hPRLrI; MFAB; Pr-1; Pr-3; PRLR; Prlr-rs1; RATPRLR; RI-PRLR
UniProt ID: (Human) P16471, (Rat) P05710, (Mouse) Q08501
Entrez Gene ID: (Human) 5618, (Rat) 24684, (Mouse) 19116
steroid biosynthetic process
activation of transmembrane receptor protein tyrosine kinase activity
JAK-STAT cascade
embryo implantation
lactation
positive regulation of cell proliferation
response to bacterium
cytokine-mediated signaling pathway
regulation of cell adhesion
regulation of epithelial cell differentiation
positive regulation of B cell proliferation
prolactin signaling pathway
activation of Janus kinase activity
negative regulation of apoptotic process
mammary gland epithelial cell differentiation
prostate gland growth
mammary gland alveolus development
mammary gland epithelium development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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