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Invitrogen
PTGR2 Polyclonal Antibody
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FIGURE: 1 / 3
PTGR2 Antibody (PA5-37089) in IHC (P)
Immunohistochemistry analysis of PTGR2 in paraffin-embedded human liver carcinoma tissue (cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with PTGR2 polyclonal antibody (Product # PA5-37089) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-37089
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 228-273 of human ZADH1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 38 kDa.
Purity is >95% by SDS-PAGE.
Target Information
ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin 13-reductase {ECO:0000250|UniProtKB:Q8VDQ1}; 15-oxoprostaglandin-delta13-reductase; epididymis secretory protein Li 298; epididymis secretory sperm binding protein; PRG-2; PRG-2 {ECO:0000250|UniProtKB:Q8VDQ1}; PRG2; Prostaglandin reductase 2; prostaglandin reductase 2 {ECO:0000250|UniProtKB:Q8VDQ1}; ptgr2 {ECO:0000250|UniProtKB:Q8VDQ1}; unnamed protein product; zinc binding alcohol dehydrogenase, domain containing 1; Zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Aliases: 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; HEL-S-298; PGR-2; PGR2; PRG-2; PTGR2; ZADH1
UniProt ID: (Human) Q8N8N7, (Rat) Q5BK81, (Mouse) Q8VDQ1
Entrez Gene ID: (Human) 145482, (Rat) 299194, (Mouse) 77219
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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